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In 2004, Hugh took on a career-changing role as the title character Fox-TV's drama series, House. The role presented Hugh with several challenges: playing against type as a sarcastic, bitter, outspokenly rude character, speaking in an American accent and walking with a cane. It also gave him the opportunity to reinvent himself for a new audience where his comedy work was largely unknown.


Season 5 premieres Tuesday, September 16 - 8/7c on Fox.

In House, Hugh stars as Dr. Gregory House, the surly, scruffy but brilliant head of a team trying to solve medical mysteries - the inexplicable cases that other doctors can't cure. A leg injury has left him with chronic pain, a pill-popping habit, and the need to walk with a cane. House is devoid of bedside manner but has observational and deductive powers worthy of Sherlock Holmes himself. He is aided by his young team of doctors on fellowships - Allison Cameron (Jennifer Morrison), Robert Chase (Jesse Spencer) and Eric Foreman (Omar Epps). He is often at odds with the hospital administrator, Dr. Cuddy (Lisa Edelstein) and his one friend on the hospital staff is the head of Oncology, Dr. James Wlison (Robert Sean Leonard).

House premiered on Fox-TV on November 16, 2004. Reviews were positive, and Hugh was singled out for praise by many critics. The show built slowly for its first two months, but when American Idol became its lead-in, the ratings took off. By the end of March, House was Fox's top-rated scripted series, even cracking the top 5 shows in the last week of March. House has become a top-20 show in the US, is seen worldwide and has made Hugh into a household name in America.

Hugh won the Television Critics Award for Lead Actor in a Drama in 2005 and 2006, as well as a Golden Globe for 2005 and 2006. He won the Screen Actors Guild Award for Male Actor in a Drama Series in 2007. He was nominated for an Emmy for Lead Actor in a Drama Series in 2005. House was nominated for the Best Drama Series Emmy in 2006, and for writing Emmys in 2005 and 2006, winning in 2005 for the episode "Three Stories," written by series creator David Shore.